Research Papers of 2021

  1. Balkrishna, A.; Tomer, M.; Verma, S.; Joshi, M.; Sharma, P.; Srivastava, J.; Varshney. Phyto-metabolite profiling of Coronil, a herbal medicine for COVID-19, its identification by mass-spectroscopy and quality validation on liquid chromatographic platforms. Journal of Separation Science 2021,44,22
  2. Balkrishna, A.; Sharma, P.; Joshi, M.; Srivastava, J.; Varshney, A. Development and validation of a rapid high-performance thin-layer chromatographic method for quantification of gallic acid, cinnamic acid, piperine, eugenol, and glycyrrhizin in Divya-Swasari-Vati, an ayurvedic medicine for respiratory ailments. Journal of Separation Science 2021
  3. Balkrishna, A.; Bhatt, A.B.; Singh, P.; Haldar, S.; Varshney, A. Comparative Retrospective Open-label Study of Ayurvedic Medicines and Their Combination with Allopathic Drugs on Asymptomatic and Mildly-symptomatic COVID-19 Patients. Journal of Herbal Medicine 2021, 100472.
  4. Balkrishna, A.; Khandrika, L.; Varshney, A. Giloy Ghanvati (Tinospora cordifolia (willd.) Hook. f. & Thomson) Reversed SARS-CoV-2 Viral Spike-protein Induced Disease Phenotype in the Xenotransplant Model of Humanized Zebrafish. Frontiers in Pharmacology 2021, 12, 534.
  5. Balkrishna, A.; Devpura, G; Tomar, B.S.; Nathiya, D.; Sharma, A.; Bhandari, D.; Haldar, S.; Varshney. A, Randomized placebo-controlled pilot clinical trial on the efficacy of ayurvedic treatment regime on COVID-19 positive patients. Phytomedicine 2021, 84, 153494.
  6. Balkrishna, A.; Mittal, R.; Sharma, G.; Vedpriya, A. Computational Insights of phytochemical Driven Disruption of RNA dependent RNA polymerase Mediated replication of Coronavirus: A Strategic Treatment Plan against COVID-19. New Microbes and New Infections 2021, 100878
  7. Balkrishna, A.; Raj, P.; Singh, P.; Varshney, A. Influence of Patient-Reported Treatment Satisfaction on Psychological Health and Quality of Life Among Patients Receiving Divya-Swasari-Coronil-Kit Against COVID-19: Findings from a Cross-Sectional “SATISFACTION COVID” Survey. Dovepress 2021, 15,899
  8. Balkrishna, A.; Haldar, S.; Singh, H.; Roy, P.; Varshney, A. Coronil, a Tri-Herbal Formulation, Attenuates Spike-Protein-Mediated SARS-CoV-2 Viral Entry into Human Alveolar Epithelial Cells and Pro-Inflammatory Cytokines Production by Inhibiting Spike Protein-ACE-2 Interaction. Journal of Inflammation Research 2021, 14,869
  9. Balkrishna, A.; Pokhrel, S.; Singh, H.; Joshi, M.; Mulay, V.P.; Haldar, S.; Varshney, A. Withanone from Withania somnifera attenuates SARS-CoV-2 RBD and host ACE2 interactions to rescue spike protein induced pathologies in humanized zebrafish model. Drug Design, Development and Therapy 2021, 15, 1111.
  10. Balkrishna, A.; Mittal, R.; Vedpriya, A. Computational Evidences of Phytochemical Mediated Disruption of PLpro Driven Replication of SARS-CoV-2: A Therapeutic Approach Against COVID-19. Current Pharmaceutical Biotechnology 2021, 22, 10.
  11. Balkrishna, A.; Pokhrel, S.; Varshney, A. Phyto-compounds from a rather poisonous plant, Strychnos nux-vomica, show high potency against SARS-CoV-2 RNA-dependent RNA polymerase. Current Molecular Medicine 2021.
  12. Balkrishna, A.; Shankar, R.; Srivastava, A.; Joshi, B.; Mishra, R.K. Role of traditional medicines as a challenge for Coronavirus (Covid-19). Indian Journal of Traditional Knowledge (IJTK) 2021, 19, S 118-S 123
  1. Balkrishna, A.; Pokhrel, S.; Varshney, A. Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain. Combinatorial Chemistry & High Throughput Screening 2020.
  2. Balkrishna, A.; Solleti, S.K.; Verma, S.; Khandrika, A.; Varshney, A. Calcio-Herbal Medicine Divya-Swasari-Vati Ameliorates SARS-CoV-2 Spike Protein-Induced Pathological Features and Inflammation in Humanized Zebrafish Model by Moderating IL-6 and TNF-α Cytokines. Journal of Inflammation Research 2020, 13, 1219.
  3. Balkrishna, A.; Solleti, S.K.; Verma, S.; Varshney, A. Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation. Molecules 2020, 25, 21, 5091.
  4. Balkrishna, A.; Thakur, P.; Singh, S.; Chandra Dev, SN.; Jain,V.; Varshney, A.; Sharma, RK. Glucose antimetabolite 2-Deoxy-D-Glucose and its derivative as promising candidates for tackling COVID-19: Insights derived from in silico docking and molecular simulations. Authorea 2020.